I think I now know what you were asking Brad and happy to provide you with my experience, although only through a FOpen and RSAUM perspective.
I have over time, adopted, tried, played, discounted, relearnt, dismissed, discovered, reused, stolen and still to be perfected my reloading and tuning practices. I'm still no good at it but at least at this stage, I can repeat most of my mistakes
In general, I would run in a gun and perform an initial load test within the first 50 rounds of a barrel's life. From that moment I might try different and smaller tests along the way i.e. free flight/seating depth, neck tension (friction, force or whatever you think is going in there), tuner tests and ES/SD comparisons. The reason I say smaller tests is because I do believe in most instances that a barrel is still work hardening/getting faster/settling down or whatever you believe until about the 150 - 200 round mark. I cannot confirm nor deny this as a reality but this is what I believe, so I deal with it.....
Once I hit that magical number, I would go back to the data that I have captured about this particular barrel and get really busy, essentially load it and take it to 1,000yds. If it shoots, bingo bango off to an OPM or Queens we go.... but more likely it takes a small amount of tinkering with the tuner to bring the group "in" to where I want it, not flat, not tall but round...
From that moment on I would never ever again try and develop a new load for that barrel, but I will continuously check to see if the load is still within the original specs i.e. Velocity, ES/SD, Length etc.
So far so good and I can tell you that one of the last barrels I took out to 1,500 shots in the SAUM was still using the exact same specs/load, as those I "developed" in the first 50 rounds.
Not sure if this helps you to move forward or sets you back further..... either way, I had fun sharing it